Table 1.
Parameter | Unit | ip |
Oral |
---|---|---|---|
50 mg/kg | 100 mg/kg | ||
Cmax | ng/mL | 26,800 ± 2884 | 325 ± 12.0 |
Tmax | h | 0.3 ± 0.1 | 0.4 ± 0.1 |
t1/2 | h | 2.0 ± 0.1 | 3.0 ± 0.4 |
AUC 0−∞ | ng/mL∙h | 54,233 ± 14,449 | 860 ± 43 |
Vz/F_obs | L/kg | 2.8 ± 0.6 | 504 ± 61 |
CL/F_obs | L/kg/h | 1.0 ± 0.2 | 116 ± 6 |