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. 2021 Sep 30;12(4):2057–2073. doi: 10.1016/j.apsb.2021.09.022

Figure 5.

Figure 5

Albumin protein corona characterization of LF-Lipo. (A) The adsorption efficiency of albumin on Lipo and LF-Lipo. (a): cell culture medium; (b): Lipo/cell culture medium; (c): LF-Lipo/cell culture medium. (B) The adsorption of serum proteins on Lipo and LF-Lipo. (C) SPARC expression of HUVEC, CT26 cell, CT26 tumor, M1Φ, and M2Φ. (D) Statistical analysis of cellular uptake of liposomes with or without BSA NP pre-treatment in CT26 cells. (E) CLSM images of the in vitro penetration of the liposomes in CT26 tumor spheroids with serum-free cell culture medium pretreatment for 12 h (scale bar = 100 μm). (d): LF-Lipo/serum-free cell culture medium; (e): LF-Lipo/cell culture medium. (F) Quantitative analysis of the penetration depth in the CT26 tumor spheroids. Data are presented as mean ± SD (n = 3). ∗∗P < 0.01, ∗∗∗∗P < 0.0001.