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Anti-angiogenic effect of LF-Lipo. (A) Illustration of the co-culture system of CT26 cells and BMDMs. (B) Expression of CD206, PD-L1, HIF-1α, and VEGF in BMDMs co-cultured with CT26 cells. (C) Illustration of the co-culture system of HUVEC and BMDMs. (D) Endothelial cell tube formation (Red arrows) after drug treatment (scale bar = 100 μm). (E) Reduced VEGFR2 and C-MYC expression in HUVEC after treatment.
