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Simplified scheme of enzymatic reactions involved in N-linked glycosylation of IgG. The major glycosylation steps and enzymes involved in N- linked glycosylation of IgGs taking place in ER and Golgi are shown. GnT, N-Acetyl glucosamine transferase; FUT, Fucosyl transferase; Man, Mannose; Gal, Galactose; GlcNAcm N-acetylglucosamine; SA, sialic acid (N-Acetylneuraminic Acid).
