Skip to main content
. 2022 Jul 13;5(11):e202201531. doi: 10.26508/lsa.202201531

Figure 3. Knockdown of pdzd8 protects flies against mitochondrial toxins.

Figure 3.

Lifespans of flies expressing pan-neuronal pdzd8-RNAi were compared with LacZ-RNAi controls when aged on a restricted diet of food containing 1% agar with 5% sucrose. (A) Lifespan with dietary restriction alone. N = 62 versus 64, median survival 20 versus 19 d, difference ns. (B) Lifespan with addition of 5% hydrogen peroxide. Median survival: 63 versus 74 h, n = 67, 74, P = 0.0002. (C) Lifespan with addition of 1 mM rotenone. Median survival: 11 versus 20 d, n = 66, 57, P < 0.0001. (D) Lifespan with addition of 5 μg/ml antimycin A. Median survival: 74 versus 68 h, n = 72, 68, P = 0.0002.