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. 2021 Dec 29;12(4):2029–2042. doi: 10.1016/j.apsb.2021.12.015

Figure 6.

Figure 6

pH-Dependent hemolysis, uptake and exocytosis. (A) Hemolysis assay. The relative hemolysis efficiency of RBCs after incubation with PPNs, EXOs and HA2 under different pH conditions is shown. ∗∗∗P < 0.001 versus pH 7.4. #P < 0.05. Error bars represent SD (n = 3). (B) TEM images of EXO@INS collected from the basolateral side of Caco-2 cell monolayer and serous side of detached intestine. Scale bar: 100 nm. (C) Cellular uptake of EXO@DiI under different pH. ∗∗P < 0.01 versus pH 7.4. Error bars represent SD (n = 3). (D) Fluorescence intensity of EXOs detained within cells. ∗∗P < 0.01, versus pH 6.0. Error bars represent SD (n = 3). (E) Cellular uptake of EXO@DiI under different pH conditions in the presence of excess HSA. ∗∗∗P < 0.001, versus pH 6.0, ##P < 0.01. Error bars represent SD (n = 3). (F) The fluorescence intensity of EXOs detained within cells in the presence of excess HSA. ∗∗P < 0.01, ∗∗∗P < 0.001, versus pH 6.0.