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. 2021 Nov 16;12(4):1567–1590. doi: 10.1016/j.apsb.2021.11.009

Figure 5.

Figure 5

Discovery of rilpivirine based on the template of dapivirine. EC50 values are obtained from Ref. 82. Drug binding pocket of rilpivirine is highlighted in HIV-1 reverse transcriptase (PDB code: 3MEG). Amino acid positions with known resistant residues are highlighted.