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. 2021 Sep 4;12(4):1723–1739. doi: 10.1016/j.apsb.2021.08.030

Figure 7.

Figure 7

The binding of PPAC, DTA, and TA with Aβ1–42. (A) Predicted binding modes of PPAC, TA and DTA against Aβ1–42 conformations. PPAC, TA and DTA are represented as cyan sticks, red sticks and yellow sticks, respectively. (B) Real-time kinetic binding sensorgrams of different concentrations of TA (12.5–400 μmol/L) are shown. Response (nm) indicates the optical thickness on the SA biosensor layer. The equilibrium binding signal (Req) revealed by the flattened curve is reached. (C) UHPLC‒DAD-Q/TOF-MS/MS analysis of Mass spectrogram of TA: S1 represents TA, S2 represents the dissociated buffer, S3 represents the blank buffer.