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Schematic diagram of this HTS method and bioactivity validation of Aβ binding small molecules from natural medicines. (1) BLI analysis by Octet® RED96e system. (2) Identification by UHPLC−DAD-Q/TOF-MS/MS. (3) Isolation of the target ingredients from natural medicines. (4) Bioactivity validation of the screened Aβ binding small-molecules in vitro and in vivo.
