. 2022 Jun 30;9:932196. doi: 10.3389/fmed.2022.932196

Table 4.

Adjusted hazard ratio for lung cancer.

		Lung cancer, all			Squamous cell carcinoma			Adenocarcinoma
		aHR	95% CI	p	aHR	95% CI	p	aHR	95% CI	p
HPV	with vs. without	1.539	1.436–1.649	<0.0001^*	1.092	0.903–1.320	0.3,653	1.714	1.572–1.870	<0.0,001^*
Gender	Male vs. Female	1.567	1.459–1.683	<0.0,001^*	5.645	4.343–7.337	<0.0,001^*	1.025	0.939–1.119	0.5798
Age
	<20	0.046	0.017–0.124	<0.0,001^*	0.239	0.028–2.045	0.1,913	0.016	0.002–0.115	<0.0,001^*
	20–40	Reference			Reference			Reference
	40–60	12.679	10.415–15.434	<0.0,001^*	26.152	10.621–64.394	<0.0,001^*	12.803	10.186–16.092	<0.0,001^*
	60–80	45.477	37.294–55.457	<0.0,001^*	155.166	63.540–378.919	<0.0,001^*	37.078	29.336–46.864	<0.0,001^*
	≥80	73.521	59.192–91.319	<0.0,001^*	267.473	107.162–667.604	<0.0001^*	51.748	39.676–67.494	<0.0,001^*
Urbanization
Urban	1	Reference			Reference			Reference
	2	0.928	0.843–1.023	0.1,321	1.282	0.971–1.692	0.0,798	0.813	0.722–0.917	0.0,007^*
	3	0.948	0.843–1.067	0.378	1.579	1.153–2.162	0.0,044^*	0.844	0.729–0.977	0.0,231^*
	4	0.914	0.802–1.041	0.1,759	1.135	0.797–1.616	0.4,842	0.746	0.631–0.883	0.00,068^*
	5	1.007	0.800–1.267	0.9,547	1.36	0.792–2.336	0.2,648	0.915	0.677–1.236	0.5,616
	6	0.84	0.688–1.025	0.0,856	1.253	0.788–1.993	0.3,409	0.683	0.522–0.894	0.0,056
Rural	7	1.093	0.889–1.342	0.3,996	1.792	1.116–2.877	0.0,158^*	0.813	0.612–1.080	0.1,529
Occupation
	Officer	0.978	0.848–1.128	0.7,635	0.594	0.356–0.994	0.0,473^*	1.098	0.929–1.298	0.2725
	Laborer	Reference			Reference			Reference
	Farmer	1.242	1.111–1.388	0.0,001^*	1.692	1.290–2.220	0.0,001^*	1.182	1.021–1.368	0.0255^*
	Low income	1.191	0.807–1.758	0.3,794	2.682	1.361–5.283	0.0,043^*	0.794	0.425–1.482	0.469
	Unemployed	1.049	0.956–1.151	0.3,116	1.082	0.842–1.389	0.5,393	1.089	0.970–1.223	0.1,482
	Others	1.223	0.927–1.614	0.1,543	0.959	0.393–2.339	0.9,259	1.327	0.956–1.844	0.0,912
Co–morbidity
	Ischemic heart disease	1.015	0.919–1.121	0.7,692	0.889	0.692–1.141	0.3,543	1.097	0.963–1.249	0.1,622
	Hypertension	1.183	1.090–1.285	<0.0,001^*	1.012	0.823–1.245	0.9,083	1.242	1.117–1.380	<0.0,001^*
	Hyperlipidemia	0.979	0.894–1.073	0.6,496	1.003	0.794–1.267	0.9,799	1.052	0.937–1.181	0.39
	Stroke	1.105	0.984–1.241	0.0,914	1.167	0.891–1.530	0.2,619	1.085	0.926–1.271	0.3117
	Diabetes mellitus	1.072	0.974–1.180	0.1,553	1.25	0.992–1.577	0.059	0.976	0.860–1.109	0.7,113
	Abnormal liver function	1.103	0.985–1.236	0.0,901	1.25	0.948–1.649	0.1,137	1.159	1.004–1.338	0.0,444
	Peptic ulcer	1.178	1.076–1.290	0.0,004^*	1.03	0.814–1.303	0.8,069	1.222	1.088–1.372	0.0,007^*
	GI bleeding	0.81	0.597–1.099	0.176	0.395	0.146–1.066	0.0,666	0.838	0.553–1.271	0.4,063
	Renal failure	1.036	0.758–1.417	0.8,233	0.893	0.410–1.946	0.7,764	0.913	0.588–1.418	0.6,867
	Chronic kidney diseases	0.988	0.770–1.267	0.9,217	0.873	0.476–1.602	0.6,616	0.975	0.695–1.368	0.883
	Gout	0.992	0.874–1.126	0.8,964	1.19	0.900–1.572	0.2,217	0.918	0.769–1.096	0.3,425
	COPD	1.799	1.613–2.007	<0.0,001^*	2.528	2.002–3.192	<0.0,001^*	1.300	1.102–1.533	0.0,018^*

COX Regression.

p < 0.05.