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. 2021 Sep 20;71(8):1567–1576. doi: 10.1136/gutjnl-2021-325181

Table 2.

Responders to GFD after 2, 6 and 12 months in relation to gender, IBS types (IBS mixed subtype, IBS-M; IBS with diarrhea IBS-D; IBS with constipation IBS-C) and HLA-DQ2/8 expression



Responders to GFD after
2 months 6 months 12 months
No Yes No Yes No Yes
N (%) 56 (43) 74 (57) 25 (30) 59 (70) 21 (24) 67 (76)
Gender*
 Female, n (%) 40 (40) 60 (60) 18 (28) 47 (72) 19 (27) 52 (73)
 Male, n (%) 16 (53) 14 (47) 7 (37%) 12 (63) 2 (12) 15 (88)
IBS type*
 IBS-M, n (%) 33 (49) 34 (51) 18 (38) 29 (62) 15 (33) 31 (67)
 IBS-D, n (%) 16 (32) 34 (68) 6 (19) 26 (81) 5 (15) 29 (85)
 IBS-C, n (%) 7 (54) 6 (46) 1 (20) 4 (80) 1 (13) 7 (87)
HLA-DQ2 or -DQ8 expression*
 DQ2/DQ8 negative, n (%) 36 (54) 31 (46) 16 (35) 30 (65) 14 (32) 30 (68)
 DQ2/DQ8 positive, n (%) 20 (37) 34 (63) 9 (27) 24 (73) 7 (19) 30 (81)

*No significant differences in the proportion of responders.

GFD, gluten-free diet; IBS, irritable bowel syndrome.