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. 2022 Apr 25;81(8):1085–1095. doi: 10.1136/annrheumdis-2021-221754

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Effects of the lead sequence variants associated with seropositive RA (18 019 cases) compared with RA overall (31 313 cases, left graph) and seronegative RA (8515 cases, right graph). The x-axis and the y-axis show the logarithmic estimated ORs for the associations with the three phenotypes. All effects are shown for the RA risk increasing allele based on current meta-analysis of study population from six countries in Northwestern Europe (table 1). Error bars represent 95% CIs. The red line represents slope (SD) based on a simple linear regression through the origin using MAF (1-MAF) as weights. See further results in table 2 and online supplemental tables 2; 3.