Table 3.

Weighted Cox regression analyses of time from birth to irreversibly reaching disability milestones

Endpoint	Events men	Censored men	Events women	Censored women	HR*, unweighted	HR*, weighted	95% CI	Cox p value
EDSS 3†	1854	988	3900	2568	1.152	1.175	1.090 to 1.266	<0.01
EDSS 4	774	2068	1322	4846	1.274	1.310	1.193 to 1.440	<0.001
EDSS 6	443	2399	701	5467	1.440	1.488	1.311 to 1.690	<0.001
Pyramidal FS score 2	619	2223	1041	5127	1.268	1.295	1.173 to 1.429	<0.001
Cerebellar FS score 2	195	2647	254	5914	1.520	1.586	1.322 to 1.902	<0.0001

*HR with women as reference.

†Proportionality not met.

EDSS, Expanded Disability Status Scale; FS, Functional System.