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. 2022 Apr 27;81(8):1136–1142. doi: 10.1136/annrheumdis-2022-222212

Figure 4.

Figure 4

Patient subsets based on peripheral blood gene expression at baseline. The cut-offs were set a priori based on an independent training data set (96 samples from patients with SLE, data not shown). The type I IFN module and the Ikaros type I IFN (eQTL) module had bimodal distributions and the cut-offs were set at the antimode: type I IFN module (IFI27, IFI44, IFI44L and RSAD2)=−1.38; Ikaros type I IFN module (HERC5, IFI6, IFIT1, MX1 and TNFRSF21)=−0.76. The distributions of Ikaros, Aiolos and B cell module were unimodal, and the cut-offs were set at the median: Ikaros (IKZF1)=−0.58; Aiolos (IKZF3)=−0.49; B cell module (CD19, BACH2 and CD22)=−0.3; T cell exhaustion module (CTLA4, IL7R, LAG3, PDCD1 and ABCE1)=−0.51. eQTL, expression quantitative trait locus; IFN, interferon.