Table 3.

Variants in TERT-CLPTM1L showing no relation to breast cancer risk in meta-analyses with at least 5000 cases and 5000 controls in additive model.

Gene	Variant	Allelesa	Cancer Type	Ethnicity	MAFb	Number evaluation		Meta-analysis risk		Heterogeneity
						Studies	Sample size (case/control)	OR (95%CI)	P value	I2(%)	P (Q)
TERT	rs13167280	G/A	Breast cancer	Caucasian	0.7312	3	10759 (5057/5702)	0.963 (0.888-1.043)	0.349	0.0	0.681
TERT	rs2075786	A/G	Breast cancer	Caucasian	0.6460	3	10759 (5057/5702)	0.996 (0.942-1.054)	0.902	0.0	0.716
TERT	rs2735940	A/G	Breast cancer	Overall	0.5282	6	12154 (5514/6640)	0.978 (0.913-1.048)	0.534	31.4	0.212
TERT	rs2735940	A/G	Breast cancer	Caucasian	0.5324	5	11495 (5446/6049)	1.006 (0.957-1.059)	0.803	83.6	< 0.001
TERT	rs2736109	G/A	Breast cancer	Overall	0.4663	8	22281 (9457/12824)	0.987 (0.922-1.056)	0.704	59.1	0.017
TERT	rs2736109	G/A	Breast cancer	Caucasian	0.4696	7	21387 (9130/12257)	0.995 (0.957-1.035)	0.809	64.8	0.009
TERT	rs2853669	T/C	Breast cancer	Caucasian	0.4864	10	18993 (8635/10358)	1.006 (0.942-1.074)	0.870	41.6	0.080
TERT	rs2853677	G/A	Breast cancer	Caucasian	0.4124	3	10759 (5057/5702)	1.036 (0.980-1.095)	0.211	0.0	0.780
TERT	rs2853690	G/T	Breast cancer	Caucasian	0.1496	3	10759 (5057/5702)	0.977 (0.905-1.054)	0.541	0.0	0.847
TERT	rs7712562	A/C	Breast cancer	Caucasian	0.2791	3	10759 (5057/5702)	1.035 (0.927-1.156)	0.540	50.4	0.133

OR, odds ratio; A, adenine; C, cytosine; G, guanine; T, thymine.

^aMajor alleles (reference)/minor alleles.

^bFrequency of minor allele in controls.