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. 2022 Jun 30;13:888248. doi: 10.3389/fimmu.2022.888248

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Copyright © 2022 Di Vito, Calcaterra, Coianiz, Terzoli, Voza, Mikulak, Della Bella and Mavilio

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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scRNA-seq profiling of NK cells from COVID-19 patients.(A) A total of 16 678 cells were embedded by Uniform Manifold Approximation and Projection (UMAP) plots in 13 clusters at a resolution level of 0.2. Each dot within the UMAP corresponds to one single cell colored according to cell cluster.(B) Ballon plots showing the expression of canonical NK cell markers in the 13 clusters identified as NK cells. Balloon size corresponds to the frequency of marker-positive cells and balloon color corresponds to the marker expression level of marker-positive cells.(C) Heatmap depicting the top 50 unique DEGs with adj. P value ≤ 0.05. Scale represents normalized counts centered and scaled across cells.(D) Ballon plots showing the expression of 33 NK cell markers to define cluster (Cl) identities. Balloon size corresponds to the frequency of marker-positive cells and balloon color corresponds to the marker expression level of marker-positive cells.(E) Heatmap showing the distribution of the 7 NK cell clusters among the 3 groups of subjects analyzed.