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. 2022 Jun 30;9:892831. doi: 10.3389/fmed.2022.892831

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Copyright © 2022 Jüngert, Paulsen, Jacobi, Horwath-Winter and Garreis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation of PIP concentration and total protein amount in analyzed tear samples. (A) Results show a significant weak negative correlation between PIP and the total protein amount in tear samples from dry eye patients (n = 115; r = −0.261, p = 0.005). (B) No correlation in tears obtained from healthy donors (n = 38). (C) A significant negative correlation in tears from evaporative dry eye patients (n = 48, r = −0.351, p = 0.015). (D,E) No significant correlation in tears from mixed (n = 48) and aqueous dry eye patients (n = 19). Correlation statistic is calculated with Spearman correlation coefficient.