Table 2.
Peripapillary and Foveal Choroidal Thickness (µm) in the Gutenberg Prematurity Eye Study (n = 408) Stratified by Gestational Age and ROP Status
| Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | |
|---|---|---|---|---|---|---|
| Gestational Age | GA ≥ 37 | GA 33–36 | GA 29–32 | GA ≤ 28 | GA ≤ 32 | GA ≤ 32 |
| No ROP | No ROP | No ROP | ROP Without Treatment | ROP With Treatment | ||
| Participants/eyes (n) | 132/241 | 134/250 | 79/144 | 16/29 | 38/57 | 9/14 |
| Choroidal thickness macula (µm) | ||||||
| Right eye | ||||||
| Foveal center | 294.0 ± 68.1 | 282.9 ± 63.5 | 285.3 ± 67.7 | 339.6 ±45.3c | 316.9± 79.8 | 250.7 ± 53.2 |
| Fovea | 293.2 ± 67.4 | 283.1 ± 61.7 | 288.0 ± 67.4 | 339.0 ±41.4c | 313.4±78.4 | 247.7 ± 49.3 |
| Inner quadrantsa | 289.6 ± 64.2 | 281.7 ± 58.8 | 288.5 ± 65.5 | 338.3 ±41.2c | 308.5± 73.3 | 242.2 ± 50.4 |
| Outer quadrantsb | 284.3 ± 61.9 | 278.4 ± 55.9 | 284.9 ± 61.3 | 334.4± 40.1c | 294.6± 67.6 | 238.2 ± 42.7c |
| Left eye | ||||||
| Foveal center | 291.0 ± 67.0 | 285.1 ± 52.9 | 292.1 ± 54.8 | 266.3 ±64.7 | 310.5 ± 66.2 | 242.0 ± 52.1c |
| Fovea | 292.5 ± 66.2 | 285.7 ± 51.0 | 292.1 ± 51.2 | 268.0 ±59.1 | 310.2 ± 64.3 | 241.2 ± 51.3c |
| Inner quadrantsa | 290.6 ± 62.2 | 285.8 ± 48.2 | 290.6 ± 47.5 | 270.3± 53.1 | 307.9 ± 64.2 | 228.3 ± 49.3c |
| Outer quadrantsb | 284.4 ± 59.1 | 282.6 ± 45.3 | 284.8 ± 45.5 | 266.5± 53.0 | 302.3 ± 64.1 | 226.3 ± 48.5c |
| Peripapillary choroidal thickness (µm) | ||||||
| Right eye | ||||||
| Global | 189 ± 60 | 184 ± 55 | 192 ± 58 | 223 ± 68 | 186 ± 60 | 187 ± 71 |
| Superotemporal | 201 ± 67 | 194 ± 58 | 204 ± 63 | 239 ± 74 | 200 ± 64 | 201 ± 80 |
| Temporal | 198 ± 74 | 195 ± 66 | 203 ± 68 | 241 ± 65c | 205 ± 67 | 198 ± 79 |
| Inferotemporal | 165 ± 60 | 164 ± 60 | 172 ± 60 | 194 ± 67 | 169 ± 66 | 172 ± 60 |
| Inferonasal | 167 ± 56 | 162 ± 55 | 173 ± 59 | 196 ± 65 | 161 ± 60 | 171 ± 64 |
| Nasal | 193 ± 62 | 187 ± 58 | 194 ± 59 | 220 ± 84 | 180 ± 64 | 181 ± 73 |
| Superonasal | 193 ± 60 | 187 ± 55 | 194 ± 61 | 233 ± 88 | 184 ± 68 | 191 ± 84 |
| Left eye | ||||||
| Global | 193 ± 58 | 187 ± 57 | 195 ± 58 | 201 ± 64 | 178 ± 52 | 187 ± 144 |
| Superotemporal | 203 ± 60 | 199 ± 62 | 209 ± 68 | 216 ± 62 | 187 ± 61 | 202 ± 147 |
| Temporal | 202 ± 67 | 196 ± 64 | 200 ± 69 | 211 ± 67 | 194 ± 59 | 202 ± 163 |
| Inferotemporal | 169 ± 58 | 164 ± 57 | 171 ± 62 | 172 ± 63 | 157 ± 54 | 180 ± 149 |
| Inferonasal | 168 ± 57 | 162 ± 60 | 170 ± 56 | 175 ± 60 | 144 ± 51c | 156 ± 116 |
| Nasal | 199 ± 63 | 193 ± 68 | 201 ± 58 | 206 ± 74 | 183 ± 58 | 182 ± 133 |
| Superonasal | 200 ± 63 | 198 ± 66 | 207 ± 65 | 211 ± 81 | 185 ± 59 | 195 ± 150 |
GA, gestational age; ROP, retinopathy of prematurity; µm, micrometer; OD, right eye; OS, left eye.
Linear regression analysis was applied to compare the different groups with the full-term control group (reference).
aMean value of the inner quadrants, bmean value of the outer quadrants, cStatistical difference (P < 0.05) compared to the full-term control group.