Table 3.
Association Analysis of Global Peripapillary and Central Subfoveal Choroidal Layer Thickness With Different Perinatal Parameters (n = 408) for the Sample of the Gutenberg Prematurity Eye Study
| Model 1 | ||
|---|---|---|
| B [95% CI] | P Value | |
| Central subfoveal choroidal thickness [µm] | ||
| Gestational age (wk) | −0.03 (−1.88 to 1.81) | 0.9 |
| Birth weight (kilogram) | 1.12 (−7.32 to 9.56) | 0.8 |
| Birth weight percentile | 0.15 (−0.17 to 0.46) | 0.4 |
| ROP (yes) | 9.4 (−17.7 to 36.5) | 0.5 |
| ROP treatment (yes) | −37.1 (−104.4 to 30.3) | 0.3 |
| Perinatal adverse events (yes) | 7.45 (−35.4 to 50.5) | 0.7 |
| Preeclampsia (yes) | 5.37 (−13.2 to 23.9) | 0.6 |
| Placental insufficiency | −6.61 (−38.6 to 25.4) | 0.7 |
| Smoking during pregnancy (yes) | −38.1 (−65.5 to −10.7) | 0.006 |
| Breastfeeding (yes) | 5.63 (−9.38 to 20.6) | 0.1 |
| Global peripapillary choroidal thickness [µm] | ||
| Gestational age (wk) | 0.38 (−0.89 to 1.64) | 0.6 |
| Birth weight (kilogram) | 3.93 (−2.11 to 9.97) | 0.2 |
| Birth weight percentile | 0.22 (−0.01 to 0.45) | 0.057 |
| ROP (yes) | −13.96 (−33.02 to 5.11) | 0.15 |
| ROP treatment (yes) | −14.97 (−70.44 to 40.5) | 0.6 |
| Perinatal adverse events (yes) | −1.99 (−27.85 to 23.86) | 0.9 |
| Preeclampsia (yes) | −0.65 (−1.36 to 0.05) | 0.068 |
| Placental insufficiency | 6.55 (−21.68 to 34.77) | 0.7 |
| Smoking during pregnancy (yes) | 13.45 (−8.06 to 34.96) | 0.2 |
| Breastfeeding (yes) | 8.52 (−2.9 to 19.93) | 0.14 |
B, beta; CI, confidence interval; µm, micrometer.
Linear regression analysis using generalized estimating equations to control for correlations between right and left eyes. Model 1 tested the association between each parameter and choroidal thickness after adjusting for age (years), sex (girls), and spherical equivalent (diopter).