Table 3.
Comparison of EORTC QLQ-FA12 scores at all time-points for selected subgroups
| Gender | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Baseline |
1 m |
3 m |
6 m |
12 m |
24 m |
60 m |
|||||||||||||||
| F (n=29) | M (n=97) | P | F (n=23) | M (n=62) | P | F (n=19) | M (n=77) | P | F (n=21) | M (n=73) | P | F (n=18) | M (n=77) | P | F (n=17) | M (n=67) | P | F (n=18) | M (n=55) | P | |
| Physical Fatigue | 33 | 28 | .33 | 62 | 50 | .036 | 59 | 59 | .73 | 40 | 37 | .97 | 22 | 18 | .67 | 25 | 22 | .58 | 27 | 22 | .63 |
| Emotional fatigue | 38 | 24 | .018 | 40 | 22 | .041 | 33 | 34 | .67 | 27 | 21 | .97 | 4 | 10 | .25 | 11 | 14 | .67 | 23 | 11 | .18 |
| Cognitive Fatigue | 26 | 13 | .009 | 22 | 11 | .10 | 20 | 18 | .60 | 17 | 10 | .27 | 6 | 8 | .87 | 6 | 6 | .31 | 17 | 8 | .46 |
| Age | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Baseline |
1 m |
3 m |
6 m |
12 m |
24 m |
60 m |
|||||||||||||||
| ≤60 (n=50) | >60 (n=76) | P | ≤60 (n=38) | >60 (n=47) | P | ≤60 (n=37) | >60 (n=59) | P | ≤60 (n=32) | >60 (n=62) | P | ≤60 (n=37) | >60 (n=58) | P | ≤60 (n=33) | >60 (n=51) | P | ≤60 (n=30) | >60 (n=43) | P | |
| Physical Fatigue | 35 | 25 | .021 | 54 | 52 | .76 | 60 | 59 | .92 | 35 | 39 | .63 | 22 | 22 | .98 | 22 | 23 | .89 | 26 | 21 | .46 |
| Emotional fatigue | 36 | 22 | .0006 | 26 | 28 | .78 | 35 | 33 | 1.00 | 22 | 22 | .87 | 10 | 9 | .88 | 13 | 15 | .59 | 18 | 11 | .41 |
| Cognitive Fatigue | 22 | 11 | .009 | 17 | 11 | .09 | 19 | 18 | .73 | 12 | 10 | .45 | 8 | 7 | .80 | 6 | 6 | .46 | 16 | 7 | .16 |
| Karnofsky Performance Score | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Baseline |
1 m |
3 m |
6 m |
12 m |
24 m |
60 m |
|||||||||||||||
| ≥90 (n=113) | <90 (n=13) | P | ≥90 (n=80) | <90 (n=5) | P | ≥90¨ (n=88) | <90 (n=8) | P | ≥90 (n=85) | <90 (n=8) | P | ≥90 (n=88) | <90 (n=7) | P | ≥90 (n=78) | <90 (n=5) | P | ≥90 (n=69) | <90 (n=4) | P | |
| Physical Fatigue | 27 | 48 | .011 | 53 | 64 | .37 | 59 | 60 | .95 | 37 | 50 | .22 | 21 | 33 | .25 | 22 | 33 | .52 | 23 | 28 | .42 |
| Emotional fatigue | 27 | 38 | .07 | 26 | 47 | .09 | 33 | 37 | .86 | 21 | 28 | .18 | 9 | 11 | .36 | 13 | 11 | .55 | 13 | 31 | .08 |
| Cognitive Fatigue | 15 | 22 | .19 | 13 | 23 | .34 | 18 | 21 | .77 | 11 | 14 | .50 | 8 | 0 | .48 | 6 | 0 | .68 | 9 | 38 | .023 |
| Chemotherapy | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Baseline |
1 m |
3 m |
6 m |
12 m |
24 m |
60 m |
|||||||||||||||
| No (n=35) | Yes (n=91) | P | No (n=20) | Yes (n=65) | P | No (n=26) | Yes (n=70) | P | No (n=26) | Yes (n=68) | P | No (n=24) | Yes (n=71) | P | No (n=22) | Yes (n=62) | P | No (n=21) | Yes (n=52) | P | |
| Physical Fatigue | 33 | 27 | .38 | 53 | 53 | .99 | 57 | 60 | .82 | 48 | 34 | .015 | 27 | 21 | .35 | 26 | 22 | .61 | 25 | 23 | 1.00 |
| Emotional fatigue | 32 | 26 | .54 | 25 | 28 | .26 | 34 | 34 | .78 | 32 | 18 | .014 | 11 | 9 | .94 | 19 | 13 | .42 | 19 | 12 | .35 |
| Cognitive Fatigue | 22 | 13 | .15 | 13 | 14 | .76 | 16 | 19 | .62 | 13 | 11 | .39 | 4 | 8 | .44 | 10 | 11 | .77 | 0 | 2 | .74 |
| Change in Fatigue level from Baseline if Non-fatigue (<10) or fatigue present (>10) at baseline | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
1 m |
3 m |
6 m |
12 m |
24 m |
60 m |
||||||||||||||||
| Non-fatigue (n=35) | Fatigue present (n=91) | P | <10 (n=35) | >10 (n=91) | P | <10 (n=35) | >10 (n=91) | P | <10 (n=35) | >10 (n=91) | P | <10 (n=35) | >10 (n=91) | P | <10 (n=35) | >10 (n=91) | P | ||||
| Physical Fatigue | 44 | 21 | .0014 | 48 | 27 | .0005 | 26 | 6 | .005 | 9 | -9 | .006 | 13 | -6 | .0056 | 8 | -7 | .0024 | |||
| Emotional fatigue | 19 | -1 | .009 | 29 | 3 | .0002 | 12 | -8 | .0038 | 4 | -24 | .0006 | 4 | -18 | .025 | 2 | -16 | .02 | |||
| Cognitive Fatigue | 7 | -8 | .001 | 13 | -7 | .0002 | 4 | -12 | <.0001 | 3 | -17 | .0014 | 1 | -20 | <.0001 | 10 | -20 | <.0001 | |||
Higher values denote more symptoms; Fisher´s nonparametric permutation test was used to compare continuous variables between groups; Bold values represent 95% significance difference between groups; Abbreviations: m=months after start of treatment; F=Female; M=Male; ≤60=up to 60 years of age at inclusion; >60=more than 60 years of age at inclusion; ≥90=KPS of 90-100; KPS of <90; No= no chemotherapy given; Yes=chemotherapy given