TABLE 1.
Candidate substances and genes for inducing ferroptosis in gastric cancer.
| Substances and Genes | Target/Function | Mechanism |
|---|---|---|
| Actinidia chinensis Planch (Gao et al., 2020) | GPx4, SLC7A11 | Induces ROS accumulation |
| Tanshinone IIA (Guan et al., 2020) | Ptgs2, Chac1, p53, xCT | Tanshinone IIA upregulates p53 expression and downregulates xCT expression; Tan IIA decreases intracellular glutathione and cysteine levels and increases the levels of intracellular ROS. |
| Tanshinone IIA (Ni et al., 2021a) | SLC7A11 | Induces ROS accumulation |
| Physcion 8-O-β-glucopyranoside (Niu et al., 2019) | GLS2 | Induces ROS accumulation |
| Erastin (Sun et al., 2020) | Mitochondrial dysfunction | Induces ROS accumulation |
| Erastin (Chen L. et al., 2020; Mao et al., 2021) | SLC7A11 | Induces ROS accumulation |
| Cysteine Dioxygenase 1 | GPX4, maintains stability of mitochondrial morphology | Mediates erastin (Hao et al., 2017); induces ROS accumulation |
| Exosomes miR-522 (Zhang et al., 2020) | ALOX15 | Leads to ALOX15 suppression, decreased lipid-ROS accumulation in cancer cells, and ultimately results in decreased chemosensitivity |
| SIRT6 (Cai et al., 2021) | GPX4 | Inhibits GPX4 activity, induces ROS accumulation |
| CPEB1 (Wang J. et al., 2021) | Gpx4 | Induces ROS accumulation |
| MiR-375 (Ni et al., 2021b) | SLC7A11 | Induces ROS accumulation |