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. 2022 Jun 30;13:927955. doi: 10.3389/fimmu.2022.927955

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Copyright © 2022 Zhang, Zhou, Jiang, He, Yao, Wang, Liu, Leptihn, Hua and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OmpA⁺ A. baumannii upregulated TNF-α and IL-6 expression levels in epithelial cells and mouse lungs. (A) TNF-α, IL-6, IL-8, and IL-1β mRNA levels in A549 cells at 6 h after infection with different A baumannii strains. (B) IL-6 and TNF-α mRNA levels in mouse lung tissue challenged with different A. baumannii strains at 48 h after infection (n = 3 per group). (C, D) ELISA of IL-6 and TNF-α in mouse (n = 5 per group) BALF (C) and serum (D) at 48 h after challenge with different A. baumannii strains. (E) Representative haematoxylin and eosin (HE)-stained images from uninfected mice (Sham) and mice infected with different A. baumannii strains. Alveolar cavity shrinking, septum thickening, interstitial diffuse oedema (arrows) are evident (n = 3 per group), scale bar, 200μm (100X), 50μm (400X). **P<0.01,*P<0.05 vs. Sham group, ^## P<0.01, ^# P<0.05.