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. 2022 Jun 30;9:940575. doi: 10.3389/fmolb.2022.940575

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Copyright © 2022 Zhang, Zhao, Liu, Shang, Chen, Zhang, He, Fan and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Landscape of the genetic alterations of the 5 FRGs and upregulated expression of the 5 FRGs is correlated with drug sensitivity in HCC. (A) The genetic alteration rates of CARS1, RPL8, TFRC, SLC1A5 and SLC7A11 in HCC were examined in the cBioPortal database. (B) The correlations between 5 FRGs and various cancer-related pathways were examined in the GSCALite database. (C) The correlations between the expression of 5 FRGs and drug sensitivity was investigated according to the GDSC database using the R package pRRophetic. Higher expression of the 5 FRGs was significantly correlated with lower IC50 values of these well-known chemotherapy drugs. The difference was compared statistically with the Wilcoxon test. *p < 0.05, **p < 0.01, ***p < 0.001.