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. 2022 Jun 30;9:940575. doi: 10.3389/fmolb.2022.940575

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Copyright © 2022 Zhang, Zhao, Liu, Shang, Chen, Zhang, He, Fan and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prognostic value and upregulated expression of five FRGs. (A) Univariate Cox regression analysis of the prognostic potential of FRGs in HCC. (B) The Kaplan–Meier curves indicate the prognostic values of CARS1, RPL8, TFRC, SLC1A5 and SLC7A11 (p < 0.05, Log-rank test). (C) Upregulated expression of CARS1, RPL8, TFRC, SLC1A5 and SLC7A11 in the TCGA combined with GTEx databases. The difference in gene expression was compared statistically with the Wilcoxon test. (D) Upregulated expression of CARS1, RPL8, TFRC, SLC1A5 and SLC7A11 in the ICGC databases. The difference in gene expression was compared statistically with the Wilcoxon test. (E) Upregulated expression of CARS1, RPL8, TFRC, SLC1A5 and SLC7A11 in GSE36376. The difference in gene expression was compared statistically with the Wilcoxon test. *p < 0.05, **p < 0.01, ***p < 0.001.