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. 2022 Jun 30;9:940575. doi: 10.3389/fmolb.2022.940575

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Copyright © 2022 Zhang, Zhao, Liu, Shang, Chen, Zhang, He, Fan and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased expression and distribution of CARS1 (A), RPL8 (B), SLC1A5 (C), SLC7A11 (D) and TFRC (E) in HCC according to single-cell RNA-seq analysis using the Human Liver Browse database (https://itzkovitzwebapps.weizmann.ac.il/webapps/home/session.html?app=HumanLiverBrowser). The left tSNE plots show the expression of 5 FRGs in 17 Seurat clusters. The identified clusters are represented by different colors. The light grey dots represent non-malignant cells (normal liver cells), the dark grey dots represent the malignant cells (HCC cells), and the different color dots represent the immune cluster, mesenchymal cluster and endothelial cluster. The right panel shows the normalized expression of each gene in different cells.