TABLE 2.
Summary of inhibitory effects of Entada africana compounds 2-5 and 7–11 (0.1/1–100 µM) from cytokine (IL-8, IL-6) release from TNFα-stimulated HaCaT cells.
| Mediator | Interleukin-8 (IL-8) | Interleukin-6 (IL-6) | ||
|---|---|---|---|---|
| Treatment | MI (%) | IC50 [95%CI] (µM) | MI (%) | IC50 [95% CI] (µM) |
| Ethyl gallate (2) | — | — | 42.5 ± 4.6 | 10.9 [6.8–17.3] |
| 5,7-dihydroxychromone (3) | — | — | — | — |
| 3′,4′,7-trihydroxyflavone (4) | 40.2 ± 5.1 | 126.2 [0.04–4.1e5] | 74.4 ± 2 | 17.8 [4.5–69.6] |
| Dihydrokaempferol-7-O-beta-D-glucopyranoside (5) | — | — | 59.3 ± 5.8 | 7.4 [2.6–20.9] |
| Quercetin-3-O-[β-apiosyl-(1‴-> 2″)-β-glucopyranoside (7) | — | — | — | — |
| Quercetin-3-O- glucopyranoside (8) | 12.8 ± 3.7 | 66.0 [0.8–5.6e4] | — | — |
| Naringenin-7-O- glucopyranoside (9) | — | — | 28.5 ± 4.6 | 42.4 [26.6–67.5] |
| Aromadendrin (10) | — | — | 67.0 ± 2.6 | 6 [4.1–8.8] |
| Myricetin-3-O- glucopyranoside (11) | 30 ± 7.9 | 184.1 [2.9e-7-1e11] | — | — |
MI, maximum inhibition, IC50, half maximal inhibitory concentration.
The values in bold represent: Single compounds with a strong inhibitory effect (≥70%).