Table 3.
Effect of hesperidin on liver function biomarkers and lipids profile in cisplatin-intoxicated rats.
| Parameters | Treatments |
|||
|---|---|---|---|---|
| Control | CIS | HES | HES + CIS | |
| ALT (U/L) | 40.40 ± 0.81c | 90.40 ± 1.91 a | 45.60 ± 1.36c | 59.00 ± 2.70b |
| AST (U/L) | 56.00 ± 2.19c | 105.20 ± 3.26 a | 56.80 ± 1.35c | 73.60 ± 3.96b |
| ALP (U/L) | 165.80 ± 7.79c | 435.40 ± 7.98 a | 162.80 ± 9.25c | 277.00 ± 16.41b |
| T. Bilirubin (mg/dl) | 0.47 ± 0.02b | 0.73 ± 0.06 a | 0.50 ± 0.002b | 0.57 ± 0.01b |
| D. Bilirubin (mg/dl) | 0.11 ± 0.005 a | 0.20 ± 0.056 a | 0.12 ± 0.004 a | 0.13 ± 0.007 a |
| Ind.Bilirubin(mg/dl) | 0.36 ± 0.02c | 0.53 ± 0.02 a | 0.38 ± 0.005 bc | 0.44 ± 0.01b |
| Total Protein (g/dl) | 7.06 ± 0.09 a | 5.88 ± 0.08c | 6.80 ± 0.09 ab | 6.48 ± 0.10b |
| Albumin (g/dl) | 4.06 ± 0.08 a | 3.87 ± 0.05 a | 3.98 ± 0.06 a | 3.86 ± 0.08 a |
| Globulin (g/dl) | 3.00 ± 0.17 a | 2.01 ± 0.06b | 2.82 ± 0.11 a | 2.62 ± 0.17 a |
| A/G ratio | 1.38 ± 0.11b | 1.93 ± 0.07 a | 1.42 ± 0.07b | 1.50 ± 0.12b |
| Glucose (mg/dl) | 96.50 ± 7.88c | 245.00 ± 10.40 a | 121.25 ± 6.42c | 208.25 ± 13.15b |
| Cholesterol (mg/dl) | 82.60 ± 2.85b | 143.60 ± 5.76 a | 70.60 ± 3.07b | 128.80 ± 8.44 a |
| Triglyceride (mg/dl) | 97.00 ± 4.23b | 134.60 ± 8.09 a | 102.40 ± 3.60b | 106.60 ± 2.99b |
Data are expressed as mean ± standard error of the mean (n = 8). Means in the same row with different superscripts letters are significantly different (p < 0.05).
Control; normal, CIS; Cisplatin, HIS; Hesperidin, ALT; Alanine aminotransferase, AST; Aspartate aminotransferase, ALP; Alkaline phosphastase, A/G ratio; Albumin/globulin ratio, D. Bilirubin; Direct bilirubin, Ind. Bilirubin; Indirect Bilirubin, T. Bilirubin; Total Bilirubin.