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. 2022 Jun 30;13:927277. doi: 10.3389/fmicb.2022.927277

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Copyright © 2022 Bi, Cui, Yao, Chang, Wang, Zhang, Xu, Zhuang and Hua.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cloning and expression of endostatin in Bifidobacterium longum. (A) Schematic representation of expression cassettes for controlled and targeted endostatin production in B. longum. (B) Expression of endostatin in probiotic strains. Lane 1: Protein marker; Lanes 2–3: L. lactis-Endo; Lane 4: L. lactis; Lane 5: L. acidophilus; Lane 6: L. acidophilus-Endo; Lanes 7–8: B. longum-Endo; and Lane 9: B. longum. (C) Expression of endostatin in B. longum. Lane 1: B. longum-Endo; Lane 2: B. longum. (D) Detection of endostatin protein expression in B. longum by immunofluorescence staining. (E) The growth curve of the recombinant strain was measured with the wild strain and MRS solution as control.