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. 2022 Jun 30;13:927277. doi: 10.3389/fmicb.2022.927277

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Copyright © 2022 Bi, Cui, Yao, Chang, Wang, Zhang, Xu, Zhuang and Hua.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B. longum-Endo administration further accelerates the recovery of DSS-induced acute inflammatory bowel disease in mice. (A) Schematic diagram of rehabilitation experimental model of acute colitis. The mice drank water normally for 5 days after taking 3% DSS for 7 days. (B) Representative photographs showing colon tissue. (C) Representative hematoxylin and eosin-stained sections of colon and histopathological scores. (D) Detection of myeloperoxidase (MPO) activity at days 7 and 12. (E) Detection of tight junction proteins ZO-1 and Occludin expression levels by qRT-PCR analysis at days 7 and 12. (F) Detection of proinflammatory cytokines TNF-α, IL-1β, and IL-6 expression levels by RT-PCR analysis at days 7 and 12. Data are expressed as mean ± SD of three independent experiments (n = 6–8). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns: not significant.