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. 2022 Jun 30;13:927277. doi: 10.3389/fmicb.2022.927277

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Copyright © 2022 Bi, Cui, Yao, Chang, Wang, Zhang, Xu, Zhuang and Hua.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B. longum-Endo inhibits AOM/DSS-induced colon tumorigenesis. (A) Schematic representation of AOM/DSS-induced colitis-associated colon cancer mouse model. (B) Body weight. (C) Representative photographs showing colon tissue at different stages. (D) The formation of solid tumors in the distal colon was observed by naked eye. (E) Tumor number and tumor size. (F,G) Representative hematoxylin and eosin-stained images and histopathological scores. (H) The 25-week survival curve after three 2% DSS cycles. Data are expressed as mean ± SD of three independent experiments (n = 6–8). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns: not significant.