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. 2022 Jun 30;13:927277. doi: 10.3389/fmicb.2022.927277

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Copyright © 2022 Bi, Cui, Yao, Chang, Wang, Zhang, Xu, Zhuang and Hua.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B. longum-Endo improved intestinal flora dysbiosis caused by AOM/DSS. (A) Principal components analysis (PCA). (B) Overview of relative abundance of microbiota at phylum level in mice. (C) The relative abundance changes of Firmicutes, Bacteroidota, Desulfobacterota, Actinobacteria, and Verrucomicrobiota after B. longum-Endo treatment. (D) Heatmap depicting the relative abundance of bacterial species at genus level for each mouse. (E) Relative abundance of representative beneficial bacteria (Lactobacillus, Bacteroides, Ileibacterium Bifidobacterium, and Allobaculum). (F) Relative abundance of representative harmful bacteria (Desulfovibrio, Helicobacter, Alistipes, and Enterorhabdus). (G) Representative differential microbiota (B. longum-Endo group vs. B. longum group, P < 0.05). *P < 0.05; **P < 0.01; ns: not significant.