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Conserved cysteine of VHA-A. VHA-A bears three conserved cysteines. Their distances of 11–29 Å exceed the maximum distance for disulfide formation. Cys256 is located in the catalytic ATP-binding P-loop, and its redox modulation efficiently inhibits V-ATPase activity. The structure is based on pdb 3j9t (Zhao et al., 2015).
