Table 2.
Effect of VIE on maximal electroshock (MES) induced convulsions.
| Groups | Tonic Flexion (s) | Tonic hind limb extension: THLE (sec) | Clonic Convulsion (sec) | Stupor (sec) | Recovery/Death |
|---|---|---|---|---|---|
| MES control | 18.17 ± 1.42 | 21 ± 0.57 | 16.83 ± 0.6 | 49.33 ± 2.01 | 50% recovered |
| STD Phenytoin 25 mg/kg | 3.5 ± 0.42*** | 1.33 ± 0.49*** | 8 ± 0.57*** | 9.83 ± 0.6*** | All recovered |
| VIE 250 mg/kg | 12.33 ± 0.98** | 16 ± 1.15** | 13.5 ± 0.67** | 40.67 ± 2.48* | 66.66% recovered |
| VIE 500 mg/kg | 6.5 ± 0.76*** | 4.83 ± 0.79*** | 9.66 ± 0.66*** | 20.33 ± 1.76*** | 83.33% recovered |
Values are expressed as Mean ± SEM for 6 animals per group.
*P < 0.05; **P < 0.01; ***P < 0.001 compared with controls (ANOVA followed by post hoc tests for multiple comparisons).