Table 3.
Effect of VIE on Isoniazid-induced seizure episodes.
| Groups | No. of animals showing convulsions | Animals protected (%) | Mortality (%) | Latency to Clonic convulsions (minutes) | Duration of Clonic convulsions (minutes) |
|---|---|---|---|---|---|
| Positive control INH (300 mg/kg) | 6/6 | 0% | 6/6 (100%) | 26.98 ± 2.46 | 4.227 ± 0.24 |
| INH + Diazepam 5 mg/kg i.p. | 0/6 | 100% | 0/6 (0%) | 77.75 ± 3.8 *** | 0.885 ± 0.21*** |
| INH + VIE 250 mg/kg p.o. | 2/6 | 66.6% | 2/6 (33.3%) | 45.45 ± 2.17 ** | 2.718 ± 0.22** |
| INH + VIE 500 mg/kg p.o. | 1/6 | 83.3% | 1/6 (16.6%) | 51.91 ± 4.18 *** | 2.135 ± 0.39*** |
Values are expressed as Mean ± SEM for 6 animals per group. **P < 0.01; ***P < 0.001compared with controls (ANOVA followed by post hoc tests for multiple comparisons).