Table 5.
Effect of VIE on GABA levels in mice brains.
| Treatment Groups |
GABA levels (ng/g of brain tissue) |
||
|---|---|---|---|
| MES | INH | PTZ | |
| Normal control | 47.5 ± 3.8 | 47.83 ± 3.7 | 52.50 ± 3.81 |
| Positive control | 23.83 ± 1.9 # | 21.83 ± 2.12 # | 24.50 ± 2.93 # |
| Phenytoin 25 mg/kg i.p. | 45.5 ± 2.93 *** | – | – |
| Diazepam 5 mg/kg i.p. | – | 43.33 ± 2.24 *** | 49.67 ± 2.90 *** |
| VIE 250 mg/kg p.o | 34.67 ± 1.3 * | 35.17 ± 2.7 * | 39 ± 2.44 * |
| VIE 500 mg/kg p.o | 41 ± 1.52 *** | 39.17 ± 2.18 *** | 42.50 ± 3.81** |
Values are Mean ± SD, n = 6 in each group. **P < 0.01,***P < 0.001 when compared with positive control groups. # P < 0.001 compared to normal control.