Table 3.
Top 4 GO terms after cluster enrichment with the 9 FH genes obtained by Enrichr-GO annotations for biological processes (BP), cellular components (CC), molecular functions (MF), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways.
| Annotation | Term | Overlap | P-value | Adjusted P-value | Odds Ratio | Combined Score | Genes |
|---|---|---|---|---|---|---|---|
| BP | MAPK cascade (GO:0000165) | 13/303 | 7.48E-16 | 9.76E-13 | 44.10362069 | 1536.088384 | CUL3; EGFR; NRAS; PIK3CA; MYC; UBC; MAPK1; GRB2; KRAS; RPS27A; HRAS; JAK3; MAPK3 |
| Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096) | 9/71 | 1.91E-15 | 9.76E-13 | 120.3931452 | 4080.57903 | CDC42; HSP90AA1; PIK3CA; SRC; PLCG2; MAPK1; GRB2; ACTB; MAPK3 | |
| Fc-gamma receptor signaling pathway (GO:0038094) | 9/72 | 2.18E-15 | 9.76E-13 | 118.4761905 | 3999.913746 | CDC42; HSP90AA1; PIK3CA; SRC; PLCG2; MAPK1; GRB2; ACTB; MAPK3 | |
| Fc receptor mediated stimulatory signaling pathway (GO:0002431) | 9/74 | 2.82E-15 | 9.76E-13 | 114.8192308 | 3846.700768 | CDC42; HSP90AA1; PIK3CA; SRC; PLCG2; MAPK1; GRB2; ACTB; MAPK3 | |
| CC | Focal adhesion (GO:0005925) | 11/387 | 1.63E-11 | 8.61E-10 | 26.0518617 | 647.0765271 | CDC42; RALA; ARF1; SRC; MAPK1; CTNNB1; KRAS; EGFR; ACTB; RHOA; MAPK3 |
| Cell-substrate junction (GO:0030055) | 11/394 | 1.98E-11 | 8.61E-10 | 25.56657963 | 630.099147 | CDC42; RALA; ARF1; SRC; MAPK1; CTNNB1; KRAS; EGFR; ACTB; RHOA; MAPK3 | |
| Vesicle (GO:0031982) | 8/226 | 2.56E-09 | 7.41E-08 | 28.9893578 | 573.5459587 | UBC; PLCG2; AKT1; RPS27A; GAPDH; EGFR; ACTB; RHOA | |
| Intracellular membrane-bounded organelle (GO:0043231) | 24/5192 | 2.51E-08 | 5.45E-07 | 7.63622291 | 133.6477075 | CREBBP; HSP90AA1; NOTCH1; HDAC1; CSNK1A1; CUL3; PTEN; EGFR; ACTB; RHOA; ZEB2; MYC; UBC; PLCG2; MAPK1; EP300; AKT1; CTNNB1; GRB2; TBL1X; RPS27A; GAPDH; TP53; MAPK3 | |
| MF | GTP binding (GO:0005525) | 7/189 | 2.09E-08 | 1.31E-06 | 29.26775148 | 517.5648946 | CDC42; RALA; ARF1; NRAS; KRAS; HRAS; RHOA |
| Phosphatase binding (GO:0019902) | 6/114 | 2.93E-08 | 1.31E-06 | 40.86213992 | 708.7297409 | MAPK1; CTNNB1; JAK3; TP53; EGFR; MAPK3 | |
| Purine ribonucleoside triphosphate binding (GO:0035639) | 9/460 | 3.93E-08 | 1.31E-06 | 16.22727273 | 276.6892164 | CDC42; RALA; ARF1; NRAS; HSP90AA1; AKT1; KRAS; HRAS; RHOA | |
| Kinase binding (GO:0019900) | 9/461 | 4.01E-08 | 1.31E-06 | 16.19054204 | 275.7614857 | CDC42; SRC; PLCG2; CTNNB1; GRB2; TP53; EGFR; ACTB; RHOA |