Table 2.
The generated pharmacophore hypotheses.
N. | Hypothesis | Phasehypo-S | Survival-S | Inactive-S | Site-S | Vector-S | Volume-S | Selectivity-S |
---|---|---|---|---|---|---|---|---|
1 | DHHRR_1 | 1.25 | 5.061 | 1.433 | 0.689 | 0.927 | 0.537 | 2.063 |
2 | ADRR_1 | 1.18 | 5.032 | 1.234 | 0.982 | 0.922 | 0.409 | 1.955 |
3 | AHHRR_1 | 1.17 | 4.964 | 1.283 | 0.725 | 0.957 | 0.502 | 1.936 |
4 | AAHHR_1 | 1.16 | 4.829 | 1.329 | 0.772 | 0.957 | 0.521 | 1.733 |
5 | ADHRR_1 | 1.15 | 4.813 | 1.698 | 0.775 | 0.898 | 0.411 | 1.775 |
6 | ADHHR_1 | 1.14 | 4.805 | 1.237 | 0.696 | 0.926 | 0.544 | 1.793 |
7 | ADHHR_2 | 1.13 | 4.798 | 1.269 | 0.701 | 0.983 | 0.465 | 1.804 |
8 | AAHHR_2 | 1.11 | 4.777 | 1.333 | 0.607 | 0.937 | 0.525 | 1.864 |
9 | ADHHR_3 | 1.10 | 4.764 | 1.464 | 0.671 | 0.961 | 0.491 | 1.797 |
10 | AAHRR_1 | 1.09 | 4.719 | 1.298 | 0.854 | 0.724 | 0.481 | 1.883 |
11 | AADHR_1 | 1.09 | 4.713 | 1.778 | 0.985 | 0.951 | 0.480 | 1.451 |
12 | HHRR_1 | 1.09 | 4.572 | 1.391 | 0.742 | 0.923 | 0.554 | 1.509 |
13 | AHHR_1 | 1.08 | 4.531 | 1.129 | 0.873 | 0.905 | 0.545 | 1.363 |
14 | DHRR_1 | 1.07 | 4.524 | 1.645 | 0.824 | 0.846 | 0.410 | 1.489 |
15 | AHHR_2 | 1.07 | 4.508 | 1.616 | 0.740 | 0.900 | 0.537 | 1.485 |
16 | DHHR_1 | 1.06 | 4.469 | 1.513 | 0.668 | 0.944 | 0.548 | 1.465 |
17 | ADHR_1 | 1.06 | 4.459 | 1.548 | 0.996 | 0.928 | 0.467 | 1.222 |
18 | AAHR_1 | 1.06 | 4.426 | 1.766 | 0.995 | 0.937 | 0.465 | 1.183 |
19 | AHRR_1 | 1.00 | 4.394 | 1.683 | 0.762 | 0.886 | 0.409 | 1.383 |
20 | AHRR_2 | 0.96 | 4.389 | 1.386 | 0.923 | 0.695 | 0.498 | 1.495 |
S: Scores