Table 1.

EMT Transcription factors, targets, and signaling pathways.

Transcription Factors	Downregulated Expression During EMT	Upregulated Expression During EMT	Regulatory Signaling Pathways	References
SNAIL1 & SNAIL2	ECAD, claudins, occludin, Crumbs 3, PALS 1, PATJ, Cytoceratines, desmoplakin, and plakophilin	Fibronectin, NCAD, collagen, MMP15, MMP2, MMP9, TWIST,I□1,I□2, ZEB1 & ZEB2	TGFβ- SMA□3, WNT –β- Catenin, Notch, P13K-AKT, NF-κ B,EGF & FGF	[26–33]
TWIST 1	ECAD, claudins, occludin, desmoplakin & plakoglobin	Fibronectin, NCAD, & α5 integrin	MAPK	[26][27][34–36]
ZEB1 & ZEB2	ECAD, ZO1, Crumbs 3 and plakophilin	NCAD, MMPs	TGFβ- SMA□3, WNT –β- Catenin, & RAS-MAPK	[26][27][37–42]
FOXT3	Unknown	unknown	β 1 integrin & laminin	[43]
FOXC2	ECAD,	Fibronectin, Vimentin, NCAD & α SMA	TGFβ- SMA□3	[44]
FOXF1	ECAD, claudin1, occludin, desmoglein 1β, desmoglein 2, □esmocollin 2, desmoplakin	Fibroectin, NCAD	unknown	[45]
FOXQ1	ECAD	Fibronectin, NCAD & Vimentin	unknown	[46]
FOXO3A	ECAD	SNAIL1	AKT	[47]
FOXA1	ECAD	Fibronectin, Vimentin, and SNAIL1	TGFβ, HGF and AKT	[48]
FOXA2	ECAD and ZO1	Fibronectin, Vimentin, NCAD, SNAIL1 & SNAIL2	TGFβ, HGF and AKT	[48]
Serpent, GATA4, AN□ GATA A6	ECAD, Xrumbs and claudins	NCAD & MMP1	unknown	[49]
HMGA2	ECAD	SNAIL1, SNAIL2 & TWIST	TGFβ, SΜA□3	[50]
SΟX9	Unknown	SNAIL2	BΜPs and PKA	[51]
KLF8	ECAD	ΜΜP9	unknown	[52]
CBFA-KAP1	Unknown	FSP1	unknown	[53]
ZNF703 (=Zeppo 1 in mice)	ECAD	Vimentin, NCAD, SNAIL1, and 27Cytokeratin	RHO-GTPase	[54]
PRΧ1	ECAD	Vimentin & Laminin	BΜP2 and TGHβ	[55]