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CTCAE Grading of hepatic adverse events.
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 | |
|---|---|---|---|---|---|
| Alanine aminotransferase (ALT) | >ULN - 3x ULN | 3-5 x ULN | 5-20 x ULN | >20 x ULN | Death |
| Aspartate aminotransferase (AST) | >ULN - 3x ULN | 3-5 x ULN | 5-20 x ULN | >20 x ULN | Death |
| Total Bilirubin | >ULN - 1.5 x ULN | 1.5-3 x ULN | 3-10 x ULN | >10 x ULN | Death |
| Alkaline phosphatase (ALP) | >ULN – 2.5 x ULN | 2.5-5 x ULN | 5-20 x ULN | >20 x ULN | Death |
