TABLE 3.
Noncoding RNAs regulate ferroptosis in cancer metastasis.
| RNAs | Targets | Functions in cancer metastasis | Referencs |
|---|---|---|---|
| Lnc-RNAs | |||
| PVT1 | miR-214 | PVT1 promotes ferroptosis by downregulating miR-214, which promotes the metastasis of NSCLC, gastric cancer and oral squamous cell carcinoma | Lu et al. (2020) |
| ZFAS1 | miR-150-5p | ZFAS1 inhibits ferroptosis by downregulating SLC38A1 by suppressing miR-150-5p level. MiR-150 is closely correlated with the metastasis of nasopharyngeal carcinoma | Liu et al. (2018), Yanni Yang et al. (2020) |
| MIR503HG | EMT-related proteins | Overexpression of MIR503HG inhibits cancer metastasis by downregulating EMT-related proteins like ZEB1 and N-cadherin | Qiu et al. (2019) |
| GAS5 | miR-23a-3p | GAS5 upregulates PTEN by sponging miR-23a-3p, thus inhibiting osteosarcoma cell invasion via the PI3K/AKT pathway | Liu et al. (2020a) |
| Circ-RNAs | |||
| TTBK2 | miR-761 and miR-1283 | CircTTBK2 promotes ferroptosis by modulating ITGB8 by sponging miR-761 in glioma. Knockdown of circ-TTBK2 inhibits proliferation, migration, invasion of glioma cells by mediating miR-1283 and CHD1 | Han et al. (2020), H-Y Zhang et al. (2020) |
| RNAs | Targets | Functions in cancer metastasis | Refs |
| IL4R | miR-541-3p/GPX4 and miR-761 | CircIL4R promotes ferroptosis in CRC cells via the miR-541-3p/GPX4 axis. It promotes the proliferation and metastasis of CRC by activating the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis | Xu et al. (2020), Tao Jiang et al. (2021) |
| mi-RNAs | |||
| miR-103a-3p | GLS2 and TPD52 | Knockdown of miR-103a-3p triggers ferroptosis in gastric cancer by downregulating GLS2. MiR-103a-3p promotes the metastasis of salivary adenoid cystic carcinoma by targeting TPD52 | Niu et al. (2019), Fu et al. (2020) |
| miR-214-3p | ATF4 | MiR-214 reduces the volume and weight of xenograft tumor tissues by enhancing Erastin-induced ferroptosis and downregulating ATF4. Plasma miR-214-3p level is significantly associated with tumor stage, recurrence and metastasis of nasopharyngeal carcinoma | Bai et al. (2020), Wang et al. (2020) |
| miR-137 | SLC1A5 and KDM1A | MiR-137 negatively regulates ferroptosis by directly targeting glutamine transporter SLC1A5 in melanoma cells. Knockdown of miR-137-3p promotes the invasiveness of CRC by upregulating KDM1A/LSD1 | Luo et al. (2018), Ding et al. (2021) |
| miR-23a-3p | DMT1 | HUCB-MSCs-exosomes inhibits ferroptosis by downregulating DMT1 via miR-23a-3p. Knockdown of miR-23a promotes the metastasis of cutaneous melanoma | Guo et al. (2017), Song et al. (2021) |