Table 1.
MR results of causal links between sleep traits and RA risk.
| Exposure | N SNP | Methods | β (95% CI) | OR (95%CI) | SE | P value | Horizontal pleiotropy | Heterogeneity | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MR-Egger | MR- | Cochran's | P | P* | F | ||||||||||||
| regression | PRESSO | Q | value | value | |||||||||||||
| Egger | SE | P | Global test | Outliers | β* | P* | |||||||||||
| intercept | value | P value | (95% CI) | value | |||||||||||||
| Short sleep | 22 | MR Egger | −0.04 (−1.28–1.21) | 0.96 (0.28–3.36) | 0.64 | 0.954 | 0.01 | 0.02 | 0.503 | 0.031 | rs60882754 | −0.04 (−1.28–1.21) | 0.954 | 23.65 | 0.258 | 0.258 | 42.65 |
| Weighted median | 0.36 (0.01–0.72) | 1.43 (1.01–2.05) | 0.18 | 0.047 | 0.36 (−0.00–0.72) | 0.068 | |||||||||||
| Inverse variance weighted | 0.39 (0.11–0.66) | 1.47 (1.12–1.94) | 0.14 | 0.006 | 0.39 (0.11–0.66) | 0.006 | |||||||||||
| Weighted mode | 0.40 (−0.16–0.96) | 1.50 (0.86–2.62) | 0.29 | 0.172 | 0.40 (−0.14–0.14) | 0.179 | |||||||||||
| Frequent insomnia | 32 | MR Egger | 0.12 (−0.38–0.62) | 1.13 (0.68–1.85) | 0.25 | 0.645 | 0.01 | 0.01 | 0.583 | 0.457 | 28.67 | 0.535 | 51.25 | ||||
| Weighted median | −0.14 (−0.37 0.10) | 0.87 (0.69–1.10) | 0.12 | 0.249 | |||||||||||||
| Inverse variance weighted | −0.01 (−0.17–0.35) | 0.99 (0.84–1.16) | 0.08 | 0.858 | |||||||||||||
| Weighted mode | −0.12 (−0.43 0.18) | 0.88 (0.65–1.20) | 0.15 | 0.430 | |||||||||||||
| Any insomnia | 33 | MR Egger | 0.01 (−0.73–0.76) | 1.01 (0.48–2.14) | 0.38 | 0.974 | 0.00 | 0.01 | 0.829 | 0.041 | rs10156602 | 0.01 (−0.74–0.77) | 0.972 | 46.52 | 0.036 | 0.028 | 39.93 |
| Weighted median | 0.08 (−0.24–0.40) | 1.08 (0.78 1.50) | 0.16 | 0.625 | 0.06 (−0.27–0.39) | 0.715 | |||||||||||
| Inverse variance weighted | 0.09 (−0.17–0.35) | 1.09 (0.85–1.42) | 0.13 | 0.489 | 0.09 (−0.18–0.35) | 0.515 | |||||||||||
| Weighted mode | 0.01 (−0.39–0.41) | 1.01 (0.67–1.51) | 0.21 | 0.964 | −0.03 (−0.42–0.36) | 0.862 | |||||||||||
| Sleep duration | 30 | MR Egger | −1.02 (−2.36–0.32) | 0.36 (0.09–1.37) | 0.68 | 0.684 | 0.01 | 0.01 | 0.354 | 0.027 | rs12215241 | −0.87 (−2.06–0.32) | 0.163 | 42.53 | 0.039 | 0.233 | 36.32 |
| Weighted median | −0.5 (−1.17–0.18) | 0.61 (0.31–1.19) | 0.34 | 0.344 | −0.5 (−1.18–0.19) | 0.157 | |||||||||||
| Inverse variance weighted | −0.43 (−0.96–0.10) | 0.65 (0.38–1.10) | 0.27 | 0.269 | −0.3 (−0.77 0.17) | 0.215 | |||||||||||
| Weighted mode | −0.66 (−1.54–0.22) | 0.52 (0.21–1.24) | 0.45 | 0.448 | −0.67 (−1.49 0.16) | 0.124 | |||||||||||
| Getting up | 43 | MR Egger | 1.46 (−2.47–5.38) | 4.29 (0.08–216.94) | 2.00 | 0.471 | 0.03 | 0.03 | 0.278 | <5e-04 | rs2193749, rs553108, rs61773374 | 0.16 (−1.37 1.69) | 0.838 | 368.25 | 0.000 | 0.165 | 28.72 |
| Weighted median | 0.22 (−0.62–1.05) | 1.24 (0.54–2.85) | 0.43 | 0.612 | −0.29 (−1.11–0.52) | 0.477 | |||||||||||
| Inverse variance weighted | −0.58 (−2.06–0.90) | 0.56 (0.13–2.46) | 0.76 | 0.442 | −0.23 (−0.80–0.35) | 0.440 | |||||||||||
| Weighted mode | −0.09 (−1.19–1.00) | 0.91 (0.30–2.72) | 0.56 | 0.867 | −0.30 (−1.30–0.70) | 0.566 | |||||||||||
| Morningness | 109 | MR Egger | 0.95 (−0.31 2.21) | 2.59 (0.73–9.16) | 0.64 | 0.142 | 0.02 | 0.01 | 0.099 | <0.0003 | rs486416, rs6716898, rs9295795 | 0.68 (−0.07–1.43) | 0.078 | 422.25 | 0.000 | 0.008 | 47.92 |
| Weighted median | 0.30 (−0.10–0.70) | 1.36 (0.91–2.02) | 0.20 | 0.136 | 0.30 (−0.09–0.69) | 0.126 | |||||||||||
| Inverse variance weighted | −0.05 (−0.51 0.41) | 0.95 (0.60–1.51) | 0.23 | 0.837 | 0.12 (−0.15–0.40) | 0.385 | |||||||||||
| Weighted mode | −0.24 (−0.84–0.36) | 0.78 (0.43–1.43) | 0.31 | 0.427 | −0.27 (−0.92–0.37) | 0.405 | |||||||||||
| Snoring | 22 | MR Egger | 1.24 (−0.41–2.88) | 3.44 (0.67–17.77) | 0.838 | 0.156 | 0.04 | 0.03 | 0.132 | 0.109 | 28.33 | 0.102 | 49.26 | ||||
| Weighted median | 0.27 (−0.11–0.66) | 1.32 (0.90–1.93) | 0.196 | 0.163 | |||||||||||||
| Inverse variance weighted | −0.05 (−0.39–0.28) | 0.95 (0.68–1.33) | 0.171 | 0.757 | |||||||||||||
| Weighted mode | 0.3 (−0.30–0.89) | 1.35 (0.74–2.434) | 0.303 | 0.336 | |||||||||||||
*
The result of recalculation after removing outliers.
>MR, Mendelian Randomization; MR-PRESSO, MR-Pleiotropy Residual Sum and Outlier method; OR, odds ratio; CI, confidence interval; IVW, inverse-variance weighted.