TABLE 1.
Characteristics of the cohorts, patients and microarray data included in the study.
| Dataset accession | First author | Country | CA vs. HCA** | Time points | Age | Sex (%males) |
Arrays | Patients | Controls | Sepsis | Bacterial | Viral | Alive | Deceased | Chip | Normalization method |
| GSE27131 | Berdal | Norway | CA | d1 d6 d7 | 41.1 | 85.7 | 21 | 14 | 7 | 7 | 0 | 7 | 5 | 2 | Affymetrix | RMA |
| GSE32707 | Dolinay | United States | CA | d1 | 57.1 | 54.2 | 103 | 103 | 55 | 48 | NA | NA | 86 | 17 | Illumina | Quantile |
| GSE40586 | Lill | Estonia | CA | d1 | 46.1 | NA | 39 | 39 | 18 | 21 | 21 | 0 | 19 | 2 | Affymetrix | RMA |
| GSE66099 | Wong | United States | CA | d1 | 3.7 | 63.1 | 276 | 276 | 77 | 199 | NA | NA | 248 | 28 | Affymetrix | gcRMA |
| GSE21802 | Bermejo-Martin | Canada | CA | d1 | NA | NA | 15 | 15 | 4 | 11 | 0 | 11 | 7 | 4 | Illumina | Quantile |
| GSE54514 | Parnell | Australia | CA | d1-d5 | 59.8 | 41.7 | 163 | 54 | 18 | 36 | 36 | 0 | 26 | 10 | Illumina | Quantile |
| GSE20346 | Parnell | Australia | CA | d1-d7 | NA | NA | 55 | 22 | 18 | 4 | 0 | 4 | 22 | 0 | Illumina | Cubic spline |
| GSE40012 | Parnell | Australia | CA | d1-d5 | NA | 45.5 | 129 | 42 | 31 | 11 | 3 | 11 | 42 | 0 | Illumina | Quantile |
| GSE57065 | Cazalis | France | CA HCA | d1 d2 d3 | 62.7 | 67.9 | 107 | 53 | 25 | 28 | 28 | 0 | 22 | 6 | Affymetrix | RMA |
| GSE60244 | Suarez | United States | CA | d1 | 62.1 | 41.5 | 158 | 158 | 40 | 118 | 47 | 96 | 158 | 0 | Illumina | Quantile* |
| GSE65682 | Scicluna | Netherland | CA HCA | d1 | 61 | 56.8 | 521 | 521 | 42 | 479 | NA | NA | 365 | 114 | Affymetrix | RMA + quantile |
| GSE95233 | Tabone | France | CA | d1 d2 d3 | 62.1 | 64.7 | 124 | 71 | 20 | 51 | NA | NA | 56 | 17 | Illumina | Quantile |
| E-MEXP-3589 | Almansa | Spain | CA | d1 | NA | 50 | 16 | 16 | 4 | 12 | 5 | 3 | 16 | 0 | Agilent | Normexp |
| E-MTAB-1548 | Almansa | Spain | HCA | d1 | 69.2 | 67.1 | 155 | 155 | 73 | 82 | NA | NA | 138 | 17 | Agilent | Normexp |
| E-MTAB-5273/5274 | Burnham | United Kingdom | CA | d1 d3 d5 | 65.4 | 53 | 337 | 253 | 10 | 243 | NA | NA | 204 | 39 | Illumina | VSN |
| GSE13015 | Planka | Thailand | CA HCA | d1 | 53.7 | 54.7 | 92 | 92 | 29 | 63 | 63 | 0 | 52 | 20 | Illumina | Quantile* |
| GSE25504 | Smith | United Kingdom | CA HCA | d1 | 0.25 | 56.8 | 88 | 88 | 44 | 44 | 37 | 5 | 84 | 4 | Illumina + Affymetrix | Spline |
|
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| Total | 2,399 | 1,972 | 515 | 1,457 | 240 | 137 | 1,181 | 276 | ||||||||
*Normalization method was not specified in the original study but was verified graphically and assumed to follow the method specified in the table based on usual methods for the associated chip.
**Community- vs. healthcare associated sepsis cases: CA is for community-acquired and HCA for healthcare-associated infections.