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. 2022 Jun 30;13:865472. doi: 10.3389/fgene.2022.865472

TABLE 1.

Clinicopathological data obtained from the TCGA database and clinical reports of breast cancer patients.

TCGA Brazilian cohort*
NT LA BLBC NT LA TNBC CT
N 75 250# 83 29 56 27 19
Median age 57.21 ± 15.67 58 ± 13.4 55 ± 13.06 55 ± 14.86 61 ± 13.13 54 ± 16.11 55 ± 14.86
Survival data, ¥ 1913 ± 1,046 1812 ± 1,304 1759 ± 1,061 n.i. 16/26 10/26 n.i.
Menopausal status, £
 Pre- 17/53 64/227 14/78 n.i 10/56 10/27 2/19
 Post- 35/53 155/227 58/78 n.i 46/56 17/27 17/19
 Peri- 1/53 8/227 6/78 n.i
Tumor size
 ≤20 mm -- n.i. n.i. 15/28 10/22 8/13 --
 >20 mm -- n.i. n.i. 13/28 12/22 5/13 --
Histological classification
 Infiltrating ductal -- 168/250 73/83 -- 34/56 25/27 --
 Infiltrating lobular -- 54/250 2/83 -- 8/56 1/27 --
 Mixed ductal and lobular -- 11/250 1/83 -- 8/56 0 --
 Others † -- 17/250 7/83 -- 6/56 1/27 --
Histological grade
 I, IA, IB -- 66/248 12/81 -- 5/24 0 --
 II, IIA, IIB -- 132/248 60/81 -- 19/24 3/12 --
 III, IIIA, IIIB, IIIC -- 46/248 9/81 -- 0 9/12 --
 IV, X -- 6/248 0/81 -- 0 0 --
Metastatic axillary lymph node
 POS 38/69 121/232 26/77 7/28 5/47 10/22 --
 NEG 31/69 111/232 51/77 21/28 42/47 12/22 --

N, number of all patients included in the study for each group. (*) The Brazilian cohort includes all the patients who have at least one of the studied samples—serum (BC-S = 67; CT = 19) or tissue (BC-T = 30; NT = 29). NT, adjacent non-tumor tissue; LA, luminal A; TNBC, triple-negative breast cancer; CT, serum samples of controls; BLBC, basal-like breast cancer; (--), not applicable; and (n.i.), not informed. (£) menopausal status of Brazilian patients was estimated based on the age of patients, and patients with peri- and post-menopausal statuses are grouped (≥50). (¥) Survival data for TCGA are represented as days to death, while the Brazilian cohort is the number of patients with data about cancer or death events. (†) includes mucinous carcinoma, tubular carcinoma, medullary carcinoma, and metaplastic carcinoma. Numbers in each parameter differ due to the lack of information for some patients. (#) LA group from the TCGA database includes four male samples, which have been removed from posterior analyses.