TABLE 1.
Clinicopathological data obtained from the TCGA database and clinical reports of breast cancer patients.
TCGA | Brazilian cohort* | ||||||
---|---|---|---|---|---|---|---|
NT | LA | BLBC | NT | LA | TNBC | CT | |
N | 75 | 250# | 83 | 29 | 56 | 27 | 19 |
Median age | 57.21 ± 15.67 | 58 ± 13.4 | 55 ± 13.06 | 55 ± 14.86 | 61 ± 13.13 | 54 ± 16.11 | 55 ± 14.86 |
Survival data, ¥ | 1913 ± 1,046 | 1812 ± 1,304 | 1759 ± 1,061 | n.i. | 16/26 | 10/26 | n.i. |
Menopausal status, £ | |||||||
Pre- | 17/53 | 64/227 | 14/78 | n.i | 10/56 | 10/27 | 2/19 |
Post- | 35/53 | 155/227 | 58/78 | n.i | 46/56 | 17/27 | 17/19 |
Peri- | 1/53 | 8/227 | 6/78 | n.i | |||
Tumor size | |||||||
≤20 mm | -- | n.i. | n.i. | 15/28 | 10/22 | 8/13 | -- |
>20 mm | -- | n.i. | n.i. | 13/28 | 12/22 | 5/13 | -- |
Histological classification | |||||||
Infiltrating ductal | -- | 168/250 | 73/83 | -- | 34/56 | 25/27 | -- |
Infiltrating lobular | -- | 54/250 | 2/83 | -- | 8/56 | 1/27 | -- |
Mixed ductal and lobular | -- | 11/250 | 1/83 | -- | 8/56 | 0 | -- |
Others † | -- | 17/250 | 7/83 | -- | 6/56 | 1/27 | -- |
Histological grade | |||||||
I, IA, IB | -- | 66/248 | 12/81 | -- | 5/24 | 0 | -- |
II, IIA, IIB | -- | 132/248 | 60/81 | -- | 19/24 | 3/12 | -- |
III, IIIA, IIIB, IIIC | -- | 46/248 | 9/81 | -- | 0 | 9/12 | -- |
IV, X | -- | 6/248 | 0/81 | -- | 0 | 0 | -- |
Metastatic axillary lymph node | |||||||
POS | 38/69 | 121/232 | 26/77 | 7/28 | 5/47 | 10/22 | -- |
NEG | 31/69 | 111/232 | 51/77 | 21/28 | 42/47 | 12/22 | -- |
N, number of all patients included in the study for each group. (*) The Brazilian cohort includes all the patients who have at least one of the studied samples—serum (BC-S = 67; CT = 19) or tissue (BC-T = 30; NT = 29). NT, adjacent non-tumor tissue; LA, luminal A; TNBC, triple-negative breast cancer; CT, serum samples of controls; BLBC, basal-like breast cancer; (--), not applicable; and (n.i.), not informed. (£) menopausal status of Brazilian patients was estimated based on the age of patients, and patients with peri- and post-menopausal statuses are grouped (≥50). (¥) Survival data for TCGA are represented as days to death, while the Brazilian cohort is the number of patients with data about cancer or death events. (†) includes mucinous carcinoma, tubular carcinoma, medullary carcinoma, and metaplastic carcinoma. Numbers in each parameter differ due to the lack of information for some patients. (#) LA group from the TCGA database includes four male samples, which have been removed from posterior analyses.