TABLE 2.

Data about receiver operating characteristic (ROC) curves to investigate the diagnostic potential of miRNAs on Brazilian tissue samples.

Comparison	miRNA	AUC	Sensitivity	Specificity	p-value
NT x BC	miR-142-5p	0.7434	66.67	96.15	0.0005
	miR-150-5p	0.8108	91.67	85.71	<0.0001
	miR-320a-3p	0.9009	74.19	81.48	<0.0001
	miR-4433b-5p	0.8462	65.38	81.48	<0.0001
	miR-150-5p + miR-320a-3p panel	0.8929	100.0	67.86	<0.0001
	miR-142-5p + miR-320a-3p panel	0.7232	89.29	46.43	0.0041
	miR-320a-3p + miR4433b-5p	0.9121	100.0	78.57	< 0.0001
	miR-142-5p + miR-320a-3p + miR-4433b-5p panel	0.9084	100.0	78.57	<0.0001
	miR-150-5p + miR-320a-3p + miR-4433b-5p panel	0.9075	100.0	78.57	<0.0001
	miRNAs complete panel*	0.8982	78.57	100.0	<0.0001
NT x LA	miR-142-5p	0.7368	61.11	100.0	0.0063
	miR-150-5p	0.8797	94.44	85.71	<0.0001
	miR-320a	0.9125	70.00	92.59	< 0.0001
	miR-4433b-5p	0.8482	68.75	81.48	0.0001
	miR-150-5p + miR-320a-3p panel	0.9079	89.29	78.95	<0.0001
	miR-142-5p + miR-320a-3p + miR-4433b-5p panel	0.9082	78.57	100.0	<0.0001
	miR-150-5p + miR-320a-3p + miR-4433b-5p panel	0.9056	78.57	100.0	<0.0001
	miRNAs complete panel*	0.8929	78.57	100.0	<0.0001
NT x TNBC	miR-142-5p	0.7571	77.78	100.0	0.0170
	miR-150-5p	0.6473	--	--	0.2092
	miR-320a	0.8799	63.64	92.59	0.0003
	miR-4433b-5p	0.8429	60.00	88.89	0.0015
	miR-150-5p + miR-320a-3p panel	0.9152	92.86	75.00	0.0004
	miR-142-5p + miR-320a-3p + miR-4433b-5p panel	0.9008	78.57	100.0	0.0003
	miR-150-5p + miR-320a-3p + miR-4433b-5p panel	0.9241	75.00	100.0	0.0003
	miRNAs complete panel*	0.9240	75.00	100.0	0.0003

(*): The four miRNAs were evaluated together. In bold and underlined are the highest AUC values for the group comparison. Only AUC>0.7 is presented, except for NT x TN, using miR-150-5p. Sensitivity and specificity are presented as percentages (%). BC, breast cancer; NT, adjacent non-tumor tissue; LA, luminal A; TNBC, triple-negative breast cancer; and (--) not evaluated.