TABLE 4.

Comparison of the expression level and performance of miR-142-5p, miR-150-5p, miR-320a, and miR-4433b-5p in tissue and serum samples (cell-free miRNAs and EVs).

	TCGA	Fresh tissue	Serum samples	EV-miRNAs#
BC x CT
miR-142-5p	high, AUC = 0.7532	low, AUC = 0.7434	n.s.	high, AUC = 0.7964
miR-150-5p	low, AUC = 0.6552	low, AUC = 0.8108	n.s.	n.s.
miR-320a	low, AUC = 0.6219	low, AUC = 0.9009	high, AUC = 0.9536	high, AUC = 0.8063
miR-4433b-5p	low, AUC = 0.6772	low, AUC = 0.8462	high, AUC = 0.8198	high, AUC = 0.7964
miR-142-5p + miR-320a	low, AUC = 0.7681	low, AUC = 0.7232	high, AUC = 0.9468	high, AUC = 0.9410
miR-142-5p + miR-320a + miR-4433b-5p	low, AUC = 0.6796	low, AUC = 0.9075	high, AUC = 0.9429	high, AUC = 0.8387
LA x CT
miR-142-5p	high, AUC = 0.7371	low, AUC = 0.7368	n.s.	high, AUC = 0.9180
miR-150-5p	low, AUC = 0.6852	low, AUC = 0.8797	n.s.	n.s.
miR-320a	low, AUC = 0.6695	low, AUC = 0.9125	high, AUC = 0.9390	high, AUC = 0.8828
miR-4433b-5p	low, AUC = 0.6279	low, AUC = 0.8482	high, AUC = 0.8375	high, AUC = 0.8672
miR-142-5p + miR-320a-3p	high, AUC = 0.7738	low, AUC = 0.9082	high, AUC = 0.9667	high, AUC = 0.9410
TNBC/BLBC x CT
miR-142-5p	high, AUC = 0.8671	n.s.	n.s.	n.s.
miR-150-5p	n.s.	n.s.	n.s.	n.s.
miR-320a	n.s.	low, AUC = 0.8799	high, AUC = 0.9830	n.s.
miR-4433b-5p	n.s.	low, AUC = 0.8429	high, AUC = 0.8063	n.s.
LA x TNBC/BLBC
miR-142-5p	low, AUC = 0.7220	n.s.	n.s.	high, AUC = 0.9208
miR-150-5p	low, AUC = 0.6322	n.s.	n.s.	high, AUC = 0.8667
miR-320a	n.s.	n.s.	n.s.	n.s.
miR-4433b-5p	n.s.	n.s.	n.s.	n.s.

#EV-miRNAs were evaluated by Ozawa (2020). Only the data that were comparable between the two studies are presented. AUC, area under the curve; n. s, not significant; BC, breast cancer; CT, control samples; LA, luminal A; TNBC, triple-negative breast cancer; and BLBC, basal-like breast cancer.