TABLE 4.
Functionally relevant SNPs allelic frequencies comparison.
| Gen | Rs | Drug | Allele frequencies a | gnomAD_general_allele frequencies | p_value | p_value_bonferroni correction | gnomAD_latin_allele frequencies | p_value | p_value_bonferroni correction |
|---|---|---|---|---|---|---|---|---|---|
| DPYD | rs1801265 | Antineoplastic | 0.698 | 0.720 | 0.141 | 1 | 0.776 | <0.01 | 0.02 b |
| SLC22A1 | rs683369 | Antineoplastic | 0.854 | 0.846 | 0.499 | 1 | 0.914 | <0.01 | 0.01 b |
| SLC15A2 | rs2257212 | Antineoplastic | 0.126 | 0.455 | <0.01 | <0.01 b | 0.309 | <0.01 | <0.01 b |
| CYP2E1 | rs2515641 | Antineoplastic | 0.755 | 0.749 | 0.663 | 1 | 0.832 | <0.01 | 0.01 b |
| ABCG2 | rs2231142 | Antineoplastic | 0.154 | 0.094 | <0.01 | <0.01 b | 0.189 | 0.048 | 1 |
| CYP1A1 | rs1048943 | Cardiovascular | 0.190 | 0.050 | <0.01 | <0.01 b | 0.315 | <0.01 | <0.01 b |
| CYP3A4 | rs2242480 | Cardiovascular | 0.208 | 0.291 | <0.01 | <0.01 b | 0.370 | <0.01 | <0.01 b |
| CYP2C19 | rs4244285 | Cardiovascular | 0.087 | 0.167 | <0.01 | <0.01 b | 0.129 | <0.01 | 0.50 |
| VKORC1 | rs7200749 | Cardiovascular | 0.028 | 0.055 | <0.01 | 0.02 b | 0.009 | <0.01 | 0.65 |
| CYP3A5 | rs10264272 | Immunosuppressant | 0.024 | 0.036 | 0.031 | 1 | 0.004 | <0.01 | 0.04 b |
| CYP3A5 | rs41303343 | Immunosuppressant | 0.005 | 0.030 | <0.01 | <0.01 b | 0.009 | 0.242 | 1 |
| SLCO1B3 | rs7311358 | Immunosuppressant | 0.785 | 0.705 | <0.01 | <0.01 b | 0.809 | 0.208 | 1 |
| ABCB1 | rs1128503 | Neuropsychiatric | 0.382 | 0.614 | <0.01 | <0.01 b | 0.534 | <0.01 | <0.01 b |
| UGT2B7 | rs4292394 | Neuropsychiatric | 0.232 | 0.577 | <0.01 | <0.01 b | 0.691 | <0.01 | <0.01 b |
| UGT2B15 | rs1902023 | Neuropsychiatric | 0.421 | 0.537 | <0.01 | <0.01 b | 0.593 | <0.01 | <0.01 b |
| NAT2 | rs1799930 | Anti-tuberculosis | 0.209 | 0.270 | <0.01 | <0.01 b | 0.150 | <0.01 | 0.14 |
| NAT2 | rs1801280 | Anti-tuberculosis | 0.322 | 0.385 | <0.01 | 0.01 b | 0.342 | 0.365 | 1 |
| NAT2 | rs1799931 | Anti-tuberculosis | 0.130 | 0.041 | <0.01 | <0.01 b | 0.131 | 0.937 | 1 |
| SLCO1B1 | rs11045819 | Anti-tuberculosis | 0.053 | 0.111 | <0.01 | <0.01 b | 0.082 | 0.014 | 1 |
| CYP2A6 | rs8192726 | Antiretrovirals | 0.040 | 0.083 | <0.01 | <0.01 b | 0.047 | 0.467 | 1 |
| CYP2B6 | rs12721646 | Antiretrovirals | 0.014 | 0.050 | <0.01 | <0.01 b | 0.012 | 0.717 | 1 |
| UGT2B7 | rs28365062 | Antiretrovirals | 0.297 | 0.155 | <0.01 | <0.01 b | 0.342 | 0.040 | 1 |
| CYP2D6 | rs16947 | Others | 0.334 | 0.614 | <0.01 | <0.01 b | 0.688 | <0.01 | <0.01 b |
| CYP2B6 | rs4803419 | Others | 0.292 | 0.282 | 0.475 | 1 | 0.455 | <0.01 | <0.01 b |
a
Present study.
b
Statistically significant.