TABLE 2.

The protective effect of compounds 3a, 3b, 3f, 3g, 3l, and 3t against H₂O₂ (150 μM)-induced injury in the PC12 cell line at different concentrations in comparison to Quercetin ^a .

Compound	n	R	R′	PC12 cell viability (% of control)
				H 2 O 2	0.1 μM	1 μM	5 μM	10 μM	20 μM	50 μM
3a	3	H	H	26.7 ± 0.8	39.4 ± 1.7	42.2 ± 1.3	53.6 ± 1.4	55.6 ± 0.1	57.4 ± 0.4	58.3 ± 1.4
3b	3	6-OMe	H	26.2 ± 0.2	31.7 ± 1.4	37.6 ± 1.1	43.3 ± 0.9	45.4 ± 1.3	49.6 ± 0.9	54.3 ± 1.6
3f	3	6-NO2	H	25.4 ± 1.5	34.1 ± 1.0	42.8 ± 1.4	43.1 ± 1.5	45.0 ± 0.8	48.3 ± 0.4	50.8 ± 0.6
3g	4	H	H	25.5 ± 0.7	30.2 ± 1.4	33.6 ± 1.2	36.6 ± 0.9	45.8 ± 0.3	48.7 ± 0.9	49.9 ± 0.9
3l	4	6-NO2	H	23.5 ± 1.0	23.7 ± 0.5	27.3 ± 1.2	33.5 ± 1.2	37.8 ± 1.0	51.6 ± 1.1	55.7 ± 2.0
3t	3	6-NO2	4-Dimethylamine	22.9 ± 0.7	38.3 ± 0.9	45.3 ± 0.7	53.6 ± 0.7	56.3 ± 1.6	68.2 ± 0.1	71.8 ± 1.1
Quercetin	—	—	—	28.0 ± 0.8	37.7 ± 1.2	44.2 ± 0.7	50.7 ± 0.1	55.8 ± 0.3	59.6 ± 0.8	61.0 ± 0.8

^aCell viability was determined using the MTT assay protocol. Data are expressed as the mean ± SEM of three independent replicates.