TABLE 4.
The protective effect of compounds 3a, 3f, and 3t against amyloid-induced injury in the SH-SY5Y cell line in comparison to Donepezil a .
| Compound | n | R | R′ | SH-SY5Y cell viability (% of control) |
|---|---|---|---|---|
| 1 µM | ||||
| 3a | 3 | H | H | 79.1 ± 4.0 |
| 3f | 3 | 6-NO2 | H | 89.0 ± 9.8 |
| 3t | 3 | 6-NO2 | H | 59.7 ± 2.8 |
| Donepezil | — | — | — | 77.1 ± 3.6 |
| Aβ 1-42 | — | — | — | 72.2 ± 7.5 |
a
Protective effects of compounds 3a, 3f and 3t on cell injury induced by Aβ1-42 in SH-SY5Ycells. All groups were treated with 5 μM Aβ1-42 except for the control group. The synthetic compounds and Donepezil were pre-incubated at 1 µm of concentration in serum-free media for 24 h before the addition of Aβ peptide. Cell viability is expressed as the mean percentage of viable cells compared with the untreated cells. The data are the mean ± SEM.