TABLE 5.
Inhibition of Aβ self- and AChE-induced aggregation by the compounds 3a, 3f, and 3t.
| Compound | Inhibition of self-induced Aβ aggregation a (%) | Inhibition of AChE-induced Aβ aggregation b (%) |
|---|---|---|
| 3a | 73.3 ± 15.4 | 76.0 ± 1.6 |
| 3f | 84.7 ± 1.6 | 87.2 ± 5.7 |
| 3t | 66.4 ± 4.7 | 52.5 ± 4.9 |
| Donepezil | 30.8 ± 1.7 | 71.9 ± 1.2 |
a
Inhibition of self-induced Aβ1-42 aggregation (20 μM) produced by the tested compound at 100 μM concentration after 48 h. Values are expressed as means ± SEM of three experiments.
b
Co-aggregation inhibition of Aβ1-42 and AChE (0.01 u/ml) by the tested compound at 100 μM concentration was detected by ThT assay. Values are expressed as means ± SEM of three experiments.