TABLE 1.
The amino acid sequence of ghrelin from a range of vertebrate species.
| Mammalian | 1* | 10 | 20 | 28 |
|---|---|---|---|---|
| Human | GSSFLSPEHQRVQQRKESKKPPAKLQPR | |||
| Mouse/Rat | GSSFLSPEHQKAQQRKESKKPPAKLQPR | |||
| Dog | GSSFLSPEHQKLQQRKESKKPPAKLQPR | |||
| Rhesus monkey | GSSFLSPEHQRAQQRKESKKPPAKLQPR | |||
| Bovine | GSSFLSPEHQKLQ - RKEAKKPSGRLKPR | |||
| Sheep | GSSFLSPEHQKLQ - RKEPKKPSGRLKPR | |||
| Avian | 1* | 10 | 20 | 26 |
| Chicken | GSSFLSPTYKNIQQQKDTRKPTARLH | |||
| Turkey | GSSFLSPAYKNIQQQKDTRKPTARLHPR | |||
| Goose | GSSFLSPEFKKIQQQNDPAKATAKIH | |||
| Fish | 1* | 10 | 20 | 23 |
| Rainbow trout | GSSFLSPSQKPQVROGKGK-PPRV-amide | |||
| Goldfish | GTSFLSPAQKPQ—GRRPPRM-amide | |||
| Zebrafish | GTSFLSPTQKPQ—GRRPPRV-amide | |||
For each species, the third amino acid of the ghrelin peptide sequence is a serine residue and is the location for acyl-modification (indicated by asterisks). As shown, there is homology between the NH2-terminal sequences of ghrelin from these vertebrate species.